Bovine Lymphosarcoma: Processing of Bovine Leukaemia Virus-coded Proteins
نویسندگان
چکیده
منابع مشابه
Bovine leukaemia virus and enzootic bovine leukosis.
Infection of bovines with bovine leukaemia virus (BLV) manifests itself in either of two ways: 30-70% of carriers develop persistent lymphocytosis (PL), with the viral genome integrated at a large number of different sites in the DNA of the affected B-lymphocytes, without causing any chromosomal abnormalities. Only 0,1-10% of carriers develop lymphoid tumours, which also consist of B-lymphocyte...
متن کاملPathology of lymphosarcoma in sheep induced with bovine leukemia virus.
Sixty-nine sheep were infected with bovine leukemia virus from bovine lymphosarcoma materials. Twenty-four developed lymphosarcoma and died from 13 to 66 (average, 29) months later. Circulating lymphocytes were increased to leukemia levels (70,000 to 403,000/cu mm blood) in only eight sheep within 2 to 3 months of death. Various lymph nodes and visceral organs including heart, abomasum, uterus,...
متن کاملTopographical analysis of tumor-associated antigens on bovine leukemia virus-induced bovine lymphosarcoma.
Tumor-associated antigens (TAAs) expressed on tumor cells from cattle with enzootic bovine leukosis were divided into three groups by using 13 monoclonal antibodies: common TAA; partially common TAA; and individually distinct TAA. TAA was extracted from tumor cells and purified by ion exchange chromatography on diethylaminoethyl-cellulose and isoelectric focusing. The common TAA, which was dete...
متن کاملBovine Leukaemia Virus onco-protein Tax antigen identification in human lymphomas tissue
Background: Bovine leukaemia virus (BLV) is the primary cause of enzootic bovine leukaemia which belongs to the HTLV/BLV group of oncogenic retroviruses including Human T-cell leukaemia virus types 1, 2, and 3 and simian T-lymphotropic virus. Due to daily consumption of milk, meat and other dairy by-products, a possible role in appearing human cancers can be assumed for BLV. Materials and Metho...
متن کاملTumor-associated antigens on bovine leukemia virus-induced bovine lymphosarcoma identified by monoclonal antibodies.
Thirteen monoclonal antibodies directed against tumor cells from cattle from enzootic bovine leukosis (EBL) were obtained. They reacted with tumor cells but not with normal bovine cells or bovine leukemia virus antigens. According to the reactivities of these antibodies with 19 individual tumors, the 13 monoclonal antibodies can be divided into three groups. Antibodies of the first group reacte...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 1983
ISSN: 0022-1317,1465-2099
DOI: 10.1099/0022-1317-64-12-2791